Figure 9
FGF-2 neutralization partially prevents the loss of visual acuity but not corneal sensation in HSV-1-infected mice. Mice were inoculated with HSV-1 or left uninfected. At days 8, 10, and 12 post infection (pi), anti-FGF-2 antibody or isotype-matched control antibody (5 μg per 10 μl PBS) were administered to infected mice by subconjunctival injection. (a) Functional vision of the mice was measured using opto-kinetic response tracking in optomotry at the indicated days pi. (b) Corneal sensation of mice was measured using a Cochet–Bonnet ethesiometer at the indicated days pi. Data represent the summary of mean±s.e.m. of two independent experiments, n=7–8 mice per group. *P<0.1, **P<0.01, ****P<0.0001 as determined by two-way ANOVA followed by Dunnet’s multiple comparisons test (comparing IgG and Anti-FGF-2-treated animals to uninfected control group).
