Figure 7
RvD1-regulated molecular pathway controlling inflammation and resolution signaling in MΦs during chronic P. aeruginosa infection. (a) The IPA map displays connections between RvD1-regulated genes and miRNAs and their functional roles in the regulation of MΦ responses to pathogens. The figure shows direct (solid lines) or indirect (dashed lines) connections between genes and miRNAs that lead to activation/causation or inhibition of indicated functions. Genes found significantly regulated by RvD1 using real time PCR analyses are indicated by filled labels. Genes encoding for proteins whose levels were determined are within boxes. (b) miRNAs regulated by RvD1 in sorted lung MΦs during RP73 infection, determined using real-time PCR. Results are mean±s.e.m. from 4 mice/group. *P=0.029; ***P<0.001 vs. MΦs from vehicle-treated infected mice. (c) Proteins encoded by RvD1-regulated genes, determined in lung homogenates 21 after infection with agar-embedded RP73 in mice treated with RvD1 or vehicle starting from day 5. Results are mean±s.e.m. from 6 to 9 mice/group. *P<0.05; **P<0.01.
