Table 1 Chronic P. aeruginosa infection-triggered lipidometabolomics

From: Resolvin D1 enhances the resolution of lung inflammation caused by long-term Pseudomonas aeruginosa infection

Mediator/precursor

  

DPI

   

0

5

21

 

Q1

Q3

Mean±s.e.m.

Mean±s.e.m.

Mean±s.e.m.

PGE2

351

271

3.70±0.14

6.51±2.60

21.17±0.66

6-keto-PGF1a

369

163

45.99±20.35

43.82±32.07

190.54±109.97

PGF2α

353

193

1.62±0.42

2.40±0.90

2.68±0.67

TXB2

369

169

9.84±4.53

6.72±5.93

48.83±51.01

LTB4

335

195

0.03±0.01

1.69±0.24

0.12±0.00

LTC4

624

272

*

*

*

LTD4

495

177

0.037±0.002

35.071±2.759

*

5-HETE

319

115

0.65±0.04

5.56±0.47

0.91±0.17

15-HETE

319

219

4.61±0.29

3.36±1.20

14.23±10.39

18-HEPE

317

259

*

0.03±0.01

0.10±0.02

7-HDoHE

343

141

0.08±0.02

0.58±0.11

0.06±0.01

14-HDoHE

343

205

8.37±0.10

8.76±0.83

71.37±15.09

17-HDoHE

343

245

8.33±4.15

1.89±0.45

25.91±16.83

7,17-diHDoHE

359

119

*

0.13±0.05

0.16±0.06

10,17-diHDoHE

359

153

0.04 0.02

0.02±0.00

0.47±0.29

  1. Abbreviations: DPI, days post infection; HDoHE, hydroxy-docosahexaenoic acid; HEPE, hydroxyeicosapentaenoic acid; HETE, hydroxyeicosatetraenoic acid; PG, prostaglandin; TX thromboxane.
  2. Select lipid mediators and precursors/markers of biosynthetic pathways in lung homogenates from mice undergoing long term infection with RP73. Results are expressed as mean±s.e.m. of ng/sample from two (0 DPI) or five (5 and 21 DPI) mice. *, below limits
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