Table 1 Summary of cDC subsets in barrier tissues

From: Development of conventional dendritic cells: from common bone marrow progenitors to multiple subsets in peripheral tissues

Tissue	Subset	cDC type	Additional markers	TFs	Cytokines	Refs
Intestine reviewed in Persson et al.¹⁰⁵	CD103⁺CD11b⁻	cDC1	XCR1, Clec9A, CadM1, CD24, CD8a	Irf8, Batf3, Id2	Flt3L, CSF-2	^{12, 30, 73, 103, 104}
	CD103⁺CD11b⁺	cDC2	CD172a, CD24	Irf4, Klf4, Notch2	Flt3L, CSF-2	^{12, 36, 44, 95, 104, 110}
	CD103⁻CD11b⁺CCR2⁻	cDC2	CD172a	Zeb2, Irf4	Flt3L	^{12, 100, 104}
	CD103⁻CD11b⁺CCR2⁺	cDC2	CD172a	Zeb2, Irf4	Flt3L	^{12, 100, 104}
Lung reviewed in Guilliams et al.¹³²	CD103⁺CD11b⁻CD207⁺	cDC1	XCR1, CadM1, Clec9A, CD24	Irf8, ID2, Batf3	Flt3L, CSF-2	^{15, 33, 34, 37, 73, 112, 133}
	CD103⁺CD11b⁻CD207⁻	cDC1	XCR1, CadM1, Clec9A, CD24	Irf8, Id2, Batf3	Flt3L, CSF-2	^{15, 33, 34, 37, 73, 103, 133}
	CD103⁻CD11b⁺CD24⁺	cDC2	CD172a, Mgl2	Zeb2, Irf4, Klf4	Flt3L	^{35, 37, 95, 100}
	CD103⁻CD11b⁺CD24⁻	cDC2	CD172a	Zeb2, Irf4	Flt3L	^{35, 37, 100}
Skin reviewed in Malissen et al.¹²²	CD207⁺CD24⁺CD103⁺	cDC1	XCR1, CadM1, Clec9A	Irf8, Batf3, Id2	Flt3L, CSF-2	^{74, 129, 133, 134}
	CD207⁺CD24⁺CD103⁻	cDC1	XCR1, CadM1, Clec9A	Irf8, Batf3, Id2	Flt3L, CSF-2	^{74, 122, 129, 134}
	CD11b⁺	cDC2	CD172a, CX3CR1, CCR2	Irf4, Zeb2?	Flt3L	^{38, 134}
	CD11b⁻ (DN)	cDC2	CD172a, CX3CR1, CCR2	Irf4, Klf4, Zeb2?	Flt3L	^{95, 134}
Nasal mucosa	CD103⁺CD11b⁻CD24⁺EpCam⁺	cDC1	XCR1? CadM1? Clec9A?	Irf8?, Batf3?, Id2?	Flt3L	¹⁰⁹
	CD103⁻CD11b⁺ CD24⁻EpCam⁺	cDC2	CD172a?	Irf4? Zeb2? Klf4?	Flt3L	¹⁰⁹
	CD103⁻CD11b⁺ CD24⁻EpCam⁻	cDC2	CD172a?	Irf4? Zeb2?	Flt3L	¹⁰⁹
	CD103⁺CD11b⁺ CD24⁺EpCam⁺	cDC2	CD172a?	Irf4, Zeb2? Klf4? Notch2?	Flt3L	¹⁰⁹
Oral mucosa	CD103⁺CD11b⁻CD207⁺	cDC1	XCR1? CadM1? Clec9A?	Irf8?, Batf3?, Id2?	Flt3L	¹¹³
	CD103⁺CD11b⁻CD207⁻	cDC1	XCR1? CadM1? Clec9A?	Irf8?, Batf3?, Id2?	Flt3L	¹¹³
	CD11b⁺	cDC2s	CD172a?	Irf4? Zeb2?	Flt3L?	¹¹³
	CD103⁺ Mucosal LC-like cells	cDC1s	XCR1? CadM1? Clec9A?	Irf8, Batf3, Id2	Flt3L	¹³⁰
	CD11b⁺ Mucosal LC-like cells	Mix of cDC2s and monocyte-derived cells	CD172a?	Irf4? Zeb2?	Part Flt3L	¹³⁰

cDC, conventional dendritic cell; LC, Langerhans cells; TFs, transcription factor.

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Table 1 Summary of cDC subsets in barrier tissues

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