Figure 6
From: MyD88-dependent dendritic and epithelial cell crosstalk orchestrates immune responses to allergens
DC costimulatory molecule expression and DC migration to mLNs are regulated by MyD88. (a) Display of the costimulatory molecules, CD40 and CD80 on lung DCs (autofluorescence– CD11c+ I-Ab hi) from untreated mice (–) and 16 h after OVA/FLA instillation (+). Mean fluorescence intensity (MFI). Data are representative of four experiments with 4–6 mice per group. (b) Migration of PKH-labeled DCs from the lung to mLNs at baseline (–) and 24 h after OVA/FLA instillation (+). Data are representative of three experiments with 3–6 mice per group. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001. DC, dendritic cells; FLA, flagellin; OVA, ovalbumin.
