Figure 1
From: The cytosolic sensor STING is required for intestinal homeostasis and control of inflammation
Alterations in mucosa structure in STING−/− mice. Small intestine and colon of wild-type (WT) and STING−/− mice were collected for analyses of (a) villi height, (c) crypt height, and (e) the number of goblet cells per crypt. Representative photomicrographies of hematoxylin and eosin–stained (b) ileum sections and (d) colon sections from WT and STING−/− mice evidencing villi and crypt height, respectively. Representative photomicrographies of periodic acid-Schiff–stained (f) colon sections from WT and STING−/− mice evidencing goblet cells (arrows). Quantification of (g) MUC1 and (i) MUC2 in the colons of WT and STING−/− mice. Representative photomicrographies of (h) MUC1 and (j) MUC2 immunohistochemical colon sections. (k) Secretory IgA (SIgA) levels in feces and (l) interleukin (IL)-1β levels in the colons of WT and STING−/− mice. (m) Quantitative reverse transcriptase–PCR analysis of Amphiregulin mRNA in the colons from WT or STING−/− mice. Bars represent 100 μm. Data represent two independent experiments with five to six mice per group. Data represent the mean±s.e.m. #P<0.05; ###P<0.001; ####P<0.0001.
