Figure 2

(a) Immunostaining for CD105 in a common acquired nevus demonstrates rare vascular structures in the superficial portions of the lesion (original magnification × 10; scale bar, 100 μm); (b) CD105+ blood vessels surrounded by nests of benign melanocytes (original magnification × 20; scale bar, 50 μm); (c) at higher power CD105 staining is observed in both luminal and cytoplasmic location in endothelial cells decorating newly formed vessels (original magnification × 40; scale bar, 25 μm); (d) CD105 in RGP melanoma shows numerous strongly positive vessels mostly in peritumoral location (original magnification × 10; scale bar, 100 μm); (e) at higher power large CD105+ blood vessels are seen in the stroma at peritumoral location (original magnification × 20, scale bar 50 μm); (f) in the context of regression, strongly CD105+ blood vessels intermingled with melanophages, fibroplasia and a mixed inflammatory infiltrate (original magnification × 20; scale bar, 50 μm); (g) thick VGP melanomas associated with numerous CD105+ intratumoral vessels (original magnification × 10; scale bar, 100 μm); (h) at higher power intratumoral vessels show strong CD105 immunostaining (original magnification × 20; scale bar, 50 μm); (i) intratumoral and peritumoral CD105+ vessels at the tumor invasive front in a VGP melanoma (original magnification × 20; scale bar, 50 μm).