Table 2 Pathways coregulated with TCL1A expression in B-cell NHL: GSEA reporting on functionally relevant pathways that are statistically significant (P<0.05, FDR<25%) and report on positive Pearson's correlation with high level of expression of TCL1A

Name of Gene-Set from GSEA	Size	ES	NES	NOM p	FDR q	Pathways
CD40 signaling during GC dev	91	0.53	1.94	0.00	0.03	GC
GC B cell	90	0.39	1.52	0.06	0.12	GC
GC T-helper cell	166	0.41	1.60	0.02	0.09	GC
Blood pan-B cell	27	0.77	2.24	0.00	0.00	BC
SMZ B cell	25	0.64	1.78	0.04	0.05	BC
BCR signal pathway	23	0.51	1.68	0.04	0.06	BC
Toll pathway	17	0.65	1.84	0.00	0.05	BC
NF-κB pathway	16	0.69	1.73	0.00	0.05	NF-κB
NF-κB target genes	18	0.52	1.31	0.20	0.21	NF-κB
TNFR2 pathway	15	0.64	1.69	0.04	0.06	NF-κB
Death pathway	23	0.43	1.33	0.13	0.19	NF-κB
IL1R pathway	19	0.52	1.48	0.08	0.14	NF-κB
IL2 pathway	18	0.49	1.46	0.13	0.15	NF-κB
IL2RB pathway	27	0.43	1.37	0.10	0.17	NF-κB
TCR pathway	30	0.49	1.67	0.02	0.06	TC
CD8 T-cell differentiation	47	0.44	1.54	0.04	0.12	TC
CD4 T-cell differentiation	78	0.40	1.53	0.00	0.12	TC
B-cell and T-cell calcium signaling	76	0.43	1.44	0.05	0.15	Calcium
Blood NK cell	18	0.49	1.45	0.10	0.14	TC
Resting dendritic cell	30	0.45	1.40	0.10	0.16	DC
Plasmacytoid dendritic cell	104	0.43	1.74	0.00	0.06	DC
CREB pathway	18	0.43	1.29	0.19	0.21	Calcium
MAPK pathway	59	0.37	1.48	0.04	0.14	NF-κB, calcium, BC, TC
BLIMP-1 targets	88	0.48	1.66	0.07	0.05	GC

GC, Germinal center; NF-κB, nuclear factor-κB pathway; BC, B cells; TC, T cells; DC, dendritic cells; calcium, calcium-signaling pathways; ES, enrichment score; NES, normalized enrichment score; NOM p, nominal P-value; SMZ, splenic marginal zone lymphoma; BCR, B-cell receptor; TNFR, tumor-necrosis factor receptor; IL, interleukin; TCR, transcription-coupled repair; NK cells, natural killer cells; CREB, cAMP response element-binding protein; MAPK, mitogen-activated protein kinase; BLIMP-1, B lymphocyte-induced maturation protein-1; GSEA, Gene-Set Enrichment Analysis.

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