Table 2 Correlation between clinicopathological characteristics and COX expression analyzed by a χ2-test
COX-1 expression | COX-2 expression | ||||||
|---|---|---|---|---|---|---|---|
Characteristic | n (%) | Negative and weak | Moderate and strong | P-value | None and weak | Moderate and strong | P-value |
All | 70 (100%) | 53 (76%) | 17 (24%) | 48 (69%) | 22 (31%) | ||
Age | 0.898 | 0.585 | |||||
<55 | 32 (46%) | 24 | 8 | 23 | 9 | ||
⩾55 | 38 (54%) | 29 | 9 | 25 | 13 | ||
Histological type | |||||||
Serous | 28 (40%) | 19 | 9 | 0.211 | 15 | 13 | 0.027 |
Endometrioid | 11 (16%) | 8 | 3 | 1 | 10 | 1 | 0.139 |
Clear cell | 22 (31%) | 18 | 4 | 0.181 | 16 | 6 | 0.501 |
Mucinous | 2 (3%) | 2 | 0 | 0 | 2 | ||
Others | 7 (10%) | 6 | 1 | 7 | 0 | ||
FIGO stage | 0.982 | 0.747 | |||||
I | 27 (39%) | 21 | 6 | 19 | 8 | ||
II | 4 (6%) | 3 | 1 | 2 | 2 | ||
III | 26 (37%) | 19 | 7 | 17 | 9 | ||
IV | 13 (19%) | 10 | 3 | 10 | 3 | ||
Tumor status | 0.767 | 0.894 | |||||
pT1+pT2 | 31 (44%) | 24 | 7 | 21 | 10 | ||
pT3 | 39 (56%) | 29 | 10 | 27 | 12 | ||
Lymph node metastasis | 0.676 | 0.699 | |||||
Negative | 56 (80%) | 43 | 13 | 39 | 17 | ||
Positive | 14 (20%) | 10 | 4 | 9 | 5 | ||
Distant metastasis | 0.32 | 0.5229 | |||||
Negative | 57 (81%) | 41 | 16 | 37 | 20 | ||
Positive | 13 (19%) | 7 | 6 | 10 | 3 | ||
Residual tumor | 0.503 | 0.736 | |||||
Optimal | 49 (70%) | 36 | 13 | 33 | 16 | ||
Suboptimal | 21 (30%) | 17 | 4 | 15 | 6 | ||
Prognosis (5 years) | 0.588 | 0.131 | |||||
Survive | 41 (59%) | 32 | 9 | 31 | 10 | ||
Death | 29(41%) | 21 | 8 | 17 | 12 | ||
Recurrence | 0.886 | 0.385 | |||||
No | 34 (49%) | 26 | 8 | 25 | 9 | ||
Yes | 36 (51%) | 27 | 9 | 23 | 13 | ||
