Figure 2

(a) Immunohistochemical staining of EphA1 in colorectal carcinomas. The expression of EphA1 in normal mucosa (EnVision, original magnification × 200). Upregulation of EphA1 in adenoma cells (right lower) compared with normal mucosas (left upper; EnVision, original magnification × 100). Downregulation of EphA1 in carcinoma cells (right upper) compared with normal mucosas (left lower; EnVision, original magnification × 200). Lost expression of EphA1 in poorly differentiated carcinoma cells (EnVision, original magnification × 400). (b) Strong immunoreactivity was detected in moderately differentiated carcinoma cells. The subcellular localization of EphA1 protein revealed the accentuation of golgiosome (EnVision, original magnification × 400). EphA1 protein was expressed homogeneously in cytoplasm (EnVision, original magnification × 400).