Table 3 Prognostic significance of clinical and pathological variables in univariate and multivariate disease-specific survival analysis

From: Intraepithelial T cells and prognosis in ovarian carcinoma: novel associations with stage, tumor type, and BRCA1 loss

Variable

Levels

Univariate

Multivariate

  

HR

CI

P

HR

CI

P

Stage

   

<0.0001

  

<0.0001

 

1

0.55

0.43–0.69

 

0.64

0.49–0.82

 
 

2

0.79

0.63–0.97

 

0.83

0.66–1.05

 
 

3

1

—

 

1

—

 

Tumor cell type

   

<0.0001

  

0.0481

 

Clear cell

1.05

0.76–1.44

 

0.78

0.49–1.23

 
 

Endometrioid

0.51

0.34–0.75

 

0.77

0.47–1.22

 
 

Mucinous

1.04

0.57–1.69

 

1.17

0.62–2.02

 
 

Serous

1

—

 

1

—

 

Silverberg grade

   

<0.0002

  

0.1100

 

1

0.56

0.39–0.77

 

0.63

0.39–0.97

 
 

2

1.24

0.94–1.63

 

1.22

0.90–1.65

 
 

3

1

—

 

1

—

 

Agea

N/A

N/A

N/A

0.0123

N/A

N/A

0.4514

Treatment

   

0.0037

  

0.3561

 

Platinum

1.26

1.08–1.47

 

1.08

0.91–1.29

 
 

Platinum and XRT

1

—

 

1

—

 

CD3+IEL

   

0.4943

  

0.3192

 

0

1.06

0.90–1.24

 

1.11

0.90–1.36

 
 

1

1

—

 

1

—

 

CD8+IEL

   

0.0269

  

0.0074

 

0

1.19

1.02–1.39

 

1.33

1.08–1.64

 
 

1

1

—

 

1

—

 
  1. IEL, intraepithelial lymphocytes; XRT, radiation therapy.
  2. aHazard ratios and confidence limits for ‘age’ are not reported due to it being modeled as a continuous variable.
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