Table 6 Frequency of KIT codon 642 and codon 822 mutations in GISTs in previously reported major studies
Source of material | Study | No. of cases | KIT mutant | ||
|---|---|---|---|---|---|
Lys642Glu | Asn822Lys Asn822His | ||||
Cancer Center, Consultation | Lasota et al5 | US/Finland | 200 | 2 (1.0%) | Not studied |
Center or University Hospital | Rubin et al11 | US | 48 | 2 (4.2%) | 2 (4.2%) |
Wardelmann et al16 | Germany | 36 | 1 (2.8%) | 0 | |
Antonescu et al27 | US | 120 | 0 | 0 | |
Kinoshita et al14 | Japan | 141 | 1 (0.7%) | 0 | |
He et al23 | China | 155 | 1 (0.7%) | 1 (0.6%) | |
Daum et al24 | Czech | 60 | 1 (1.7%) | 0 | |
Cho et al21 | Japan | 69 | 1 (1.5%) | 0 | |
Cho et al22 | |||||
Subtotal: | 829/629 | 9 (1.1%) | 3 (0.5%) | ||
Imatinib mesylate clinical trial | Heinrich et al4 | US | 127 | 2 (1.6%) | 2 (1.6%) |
Debiec-Rychter et al28 | Europe | 377 | 6 (1.6%) | 3 (0.8%) | |
Subtotal: | 504 | 8 (1.6%) | 5 (1%) | ||
Population based | Andersson et al20 | Sweden | 177 | 0 | 1 (0.6%) |
Steigen et al25 | Norway | 89 | 3 (3.4%) | 1 (1.1%) | |
Subtotal: | 266 | 3 (1.1%) | 2 (0.75%) | ||
