Figure 1
From: TMPRSS2-ERG gene fusions are infrequent in prostatic ductal adenocarcinomas
Top panel: low-power photomicrograph of the H&E stained radical prostatectomy slide with ductal adenocarcinoma focus circled in red and acinar adenocarcinoma focus circled in blue (Case 30). The ductal and acinar tumors are separated spatially and appear to be discrete tumor foci. Middle panels: digitally scanned images of an H&E stained section of the 0.6 mm cores punched for the tissue microarray from each tumor area (40 × magnification). Bottom panels: ERG break-apart FISH images from ductal and acinar tumor foci (all 1000 × magnification). Case 30 shows the TMPRSS2-ERG fusion through deletion in the ductal adenocarcinoma (left panel), with one juxtaposed red–green (yellow) signal in each nucleus and absence of the second green signal (arrows, inset). The acinar component of Case 30 (right panel) shows no evidence of TMPRSS2-ERG fusion with two pairs of juxtaposed red–green signals in each nucleus (arrows, inset).
