Figure 1
Main histological characteristics and expression patterns of endothelial cell markers in three patients. (H&E stain and CD34, CD31, and von Willebrand factor immunohistochemistry. Scale bar=100 μm). H&E histology: In patient 2, aggressive vascular proliferation disrupted a fibrous fascia (asterisk); in patient 3, angiogenesis was less extensive and had an angioma-like aspect (arrows); in patient 4, angiogenesis involved dilated or branching venules. Endothelial cell marker immunohistochemistry: Patient 2: CD34-panel clearly shows the prominent periarterial (a) and perivenous (v) distribution of the massive angiogenesis. In patient 2 CD31-panel, endothelial labeling confirmed that the fibrous fascia was disrupted by angiogenesis. In the three patients, all the newly formed vessels strongly expressed all the endothelial markers tested.
