Table 5 Analysis of discordant cases
From: Histopathologic variables predict Oncotype DX™ Recurrence Score
Nottingham Grade | RS | No. of cases | Explanation |
|---|---|---|---|
1 | Intermediate | 5 | Recurrence scores for these five cases (range, 19–21) are in the lower end of the intermediate category. All have grade 2 nuclei. One case has a very low ER immunohistochemical score (110) and one case has a very low PR immunohistochemical score (1) |
2 | Low | 9 | These nine cases have a high mean ER immunohistochemical score (221), high mean PR immunohistochemical score (166), and all are HER-2/neu negative |
2 | High | 3 | These three cases have a low mean ER immunohistochemical score (143.3), a low mean PR immunohistochemical score (58.3) and two cases are HER-2/neu positive. The one HER-2/neu negative case has the lowest ER immunohistochemical score |
3 | Intermediate | 1 | Although this case has a Nottingham score of 9, it has a very high ER IHC-score (255), high PR IHC-score (190), and is HER-2/neu negative |
