Figure 5
(a and b) Survival curves with different extents of the micropapillary pattern (N=383). The disease-free and overall survival of the focal group (N=65) were worse than those of the none group (N=199) (P=0.027 and P=0.068). (c and d) Survival curves grouped by the presence of the micropapillary pattern and dominant histological subtype. Black, blue, red, and green lines show dominant bronchioloalveolar carcinoma (N=103), acinar (N=69), papillary (N=182), and solid with mucin subtype (N=29), respectively. Solid and dotted lines show micropapillary pattern-positive and pattern-negative, respectively. No significant differences in survival between dominant acinar, papillary, and solid with mucin carcinomas were found. The difference between micropapillary pattern-positive and pattern-negative carcinomas was significant in the dominant papillary subtype (red) for disease-free survival (P=0.008) and in the dominant bronchioloalveolar carcinoma subtype (black) for overall survival (P=0.046). Differences were observed in other subtypes, but they were small and not significant. (e and f) The 5-year and 10-year overall survival rates of the micropapillary pattern-positive group (N=78) were 77.6 and 67.6%, respectively, which were significantly worse than those of the micropapillary pattern-negative group (N=119) (98.1 and 98.1%) in stageIA.
