Table 1 MDM2 gene amplification by FISH in a variety of soft tissue neoplasms
Soft tissue tumor | MDM2 amplification (mean signal gains per cell) | CEP12 amplification (mean signal gains per cell) | Ratio MDM2/CEP12 | Interpretation |
|---|---|---|---|---|
Lipoma (n=10) | 0/10 (1.8) | 0/10 (2.0) | 0.9 | Absent |
Angiolipoma (n=10) | 0/10 (1.9) | 0/10 (2.1) | 0.9 | Absent |
Spindle cell/pleomorphic lipoma (n=9) | 8/9 (3.4) | 8/9 (3.6) | 0.9 | Polysomic |
Lipoblastoma (n=1) | 0/1 (2.1) | 0/1 (2.3) | 0.9 | Absent |
Well-differentiated liposarcoma/atypical lipomatous tumor (n=13) | 13/13 (16.0) | 0/13 (2.3) | 7.2 | Present |
Dedifferentiated liposarcoma (n=14) | 14/14 (18.2) | 0/14 (2.3) | 8.2 | Present |
Pleomorphic sarcoma, not otherwise specified (n=10) | 10/10 (5.1) | 10/10 (3.3) | 1.6 | 40% present |
Myxoid malignant fibrous histiocytoma/myxofibrosarcoma (n=1) | 0/1 (2.0) | 1/1 (4.1) | 0.5 | Absent |
Extra-skeletal myxoid chondrosarcoma (n=10) | 0/10 (2.0) | 0/10 (2.0) | 1.0 | Absent |
Clear cell sarcoma (n=4) | 0/4 (2.0) | 0/4 (2.0) | 1.0 | Absent |
Low-grade fibromyxoid sarcoma (n=10) | 0/10 (2.0) | 0/10 (2.0) | 1.0 | Absent |
Myxoid liposarcoma (n=5) | 1/5 (2.9) | 0/5 (2.1) | 1.4 | 20% present 80% absent |
Solitary fibrous tumor/hemangiopericytoma (n=10) | 0/9 (2.0) | 0/9 (2.0) | 1.0 | Absent |
Epithelioid sarcoma (n=1) | 1/1 (20.0) | 0/1 (2.0) | 10.0 | Present |
Malignant melanoma (n=1) | 0/1 (2.0) | 0/1 (2.0) | 1.0 | Absent |
Neuroblastoma (n=1) | 0/1 (2.0) | 0/1 (2.0) | 1.0 | Absent |
Ewing's sarcoma (n=3) | 0/3 (2.0) | 0/3 (2.0) | 1.0 | Absent |
Desmoplastic small round cell tumor (n=1) | 0/1 (2.0) | 0/1 (2.0) | 1.0 | Absent |
Alveolar rhabdomyosarcoma (n=3) | 0/3 (2.0) | 0/3 (2.0) | 1.0 | Absent |
Gastrointestinal stromal tumor (n=4) | 0/4 (2.00) | 0/4 (2.00) | 1.0 | Absent |
Leiomyosarcoma (n=1) | 0/1 (2.0) | 0/1 (2.0) | 1.0 | Absent |
Synovial sarcoma (n=4) | 0/4 (2.0) | 0/4 (2.0) | 1.0 | Absent |
Malignant peripheral nerve sheath tumor (n=4) | 1/4 (6.5) | 0/4 (2.0) | 3.3 | 25% present 75% absent |
