Figure 1

Representative results of immunohistochemical staining. High panels show tissue at × 100 magnification and lower panels show tissue at × 400 magnification. (a) BMP-6 expression was low in nodular hyperplasia and was higher in prostatic intraepithelial neoplasia and prostate cancer. The expression of BMP-6 was significantly higher in prostate cancer compared with nodular hyperplasia. (b) Noggin expression was very much similar among nodular hyperplasia, prostatic intraepithelial neoplasia and prostate cancer. The differences among the groups were not statistically significant. (c) Sclerostin expression was higher in nodular hyperplasia and prostatic intraepithelial neoplasia and was lower in prostate cancer. The expression of sclerostin was significantly higher in nodular hyperplasia compared with prostate cancer. (d, e) Two cases showing staining with relatively high level of BMP-6 and low levels of both noggin and sclerostin. These two patients developed distant metastasis in bone.