Table 1 Clinicopathological parameters from 122 of the 125 prostatic adenocarcinoma patients

From: Absence of TMPRSS2:ERG fusions and PTEN losses in prostate cancer is associated with a favorable outcome

Clinicopathological parameters

Number of cases

TMPRSS2:ERG

P-value

  

Not fused

Fusion

 

Preoperative PSA (ng/ml) a

   

0.612

 0.9–4.0

9

3 (33.33)

6 (66.67)

 

 4.0–10.0

58

31 (53.45)

27 (46.55)

 

 10.1–20.0

37

21 (56.76)

16 (43.24)

 

 20.1–84.0

15

7 (46.67)

8 (53.33)

 

Median tumor volume (%) a

   

0.886

 0–10.0

35

19 (54.29)

16 (45.71)

 

 10.1–20.0

28

14 (50.00)

14 (50.00)

 

 20.1–85.0

49

24 (48.98)

25 (51.02)

 

Gleason score

   

0.636

 4–6

74

39 (52.70)

35 (47.30)

 

 7

35

18 (51.43)

17 (48.57)

 

 8–9

13

5 (38.46)

8 (61.54)

 

Pathologic stage

   

0.966

 pT2a

10

6 (60.00)

4 (40.00)

 

 pT2b

58

30 (51.72)

28 (48.28)

 

 pT3a

39

19 (48.72)

20 (51.28)

 

 pT3b

9

4 (44.44)

5 (55.56)

 

 pT4

6

3 (50.00)

3 (50.00)

 

Seminal vesicle invasion a

   

0.337

 Negative

108

54 (50.00)

54 (50.00)

 

 Positive

9

6 (66.67)

3 (33.33)

 

Perineural infiltration

   

0.344

 Negative

18

11 (61.11)

7 (38.89)

 

 Positive

104

51 (49.04)

53 (50.96)

 

Angiolymphatic invasion a

   

0.400

 Negative

89

43 (48.31)

46 (80.70)

 

 Positive

26

15 (57.69)

11 (19.30)

 

Capsular invasion a

   

0.387

 Negative

52

29 (55.77)

23 (44.23)

 

 Positive

69

33 (47.83)

36 (52.17)

 

Extraprostatic extension a

   

0.835

 Negative

92

46 (50.00)

50 (50.00)

 

 Positive

19

9 (47.37)

10 (52.63)

 

Lymphonodal invasion a

   

0.154

 Negative

108

53 (49.07)

55 (50.93)

 

 Positive

2

2 (100.00)

0 (0.00)

 

Biochemical recurrence

   

0.047

 Negative

62

37 (59.68)

25 (40.32)

 

 Positive

60

25 (41.67)

35 (58.33)

 
  1. aValues not available for all 122 cases.
  2. The three atypical cases were excluded from the clinicopathological correlation analysis given that complex genomic rearrangement involving an unknown chromosomal partner(s) could not be elucidated as previously described.
  3. Median overall survival was 87.4 months (11.5–161.6).
  4. Values in parentheses indicate the percentage of sample in each category.
  5. P-value=χ2-analysis.