Table 1a  Summary of histologic scores for DDR markers in normal ductal epithelium, PanINs, and pancreatic ductal adenocarcinomas

From: Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia

Antibody

Normal duct (N=73)

PanIN-1 (N=31)

PanIN-2 (N=14)

PanIN-3 (N=13)

Adenocarcinoma (N=81)

ANOVA P-value

pγH2AXSer139

2.36

4.34

6.21

7.50

4.53

<0.0001a

pATMSer1981

2.33

4.83

5.14

7.17

4.84

<0.0001a

pChk2Thr68

2.75

5.43

7.64

5.44

2.43

<0.0001a

p53

0

1.41

1.86

4.00

4.22

<0.0001a

  1. DDR, DNA damage response and PanIN, pancreatic intraepithelial neoplasia.
  2. aSignificant at the level of P-value < 0.05.
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