Table 1b  Statistically significant differences in histologic scores for DDR markers in PanINs and in adenocarcinomas, compared to histologic score in the non-neoplastic ductal epithelium

From: Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia

Antibody

PanIN-1 (N=31)

PanIN-2 (N=14)

PanIN-3 (N=13)

Adenocarcinoma (N=81)

pγH2AXSer139

P<0.05a

P<0.05a

P<0.05a

P<0.05a

pATMSer1981

P<0.05a

P<0.05a

P<0.05a

P<0.05a

pChk2Thr68

P<0.05a

P<0.05a

P<0.05a

NS

p53

NS

NS

P<0.05a

P<0.05a

  1. DDR, DNA damage response; NS, not significant and PanIN, pancreatic intraepithelial neoplasia.
  2. aSignificant at the level of P-value < 0.05, Post-hoc Duncan's multiple range test.
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