Table 4 Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and concordance of MLPA with chromogenic in situ hybridization for TopoII α and HER2 using cut-off values of 1.5 and 1.8 to discriminate between no amplification and low level amplification status

From: Simultaneous detection of TOP2A and HER2 gene amplification by multiplex ligation-dependent probe amplification in breast cancer

 

Sensitivity

Specificity

PPV

NPV

Concordance

TopoIIα 1.5

86.7

92.6

39.4

99.2

91.2

TopoIIα 1.8

73.3

99.6

91.7

98.5

97.5

HER2 1.5

88.9

98.4

88.9

98.4

96.1

HER2 1.8

75.0

99.6

96.4

96.5

95.8

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