Figure 2 | Modern Pathology

Figure 2

From: Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms

Figure 2

Sox11 expression in plasma cell myeloma. H&E (left), immunohistochemical stain for cyclin D1 (middle), fluorescence in situ hybridization (FISH) for t(11;14)-CCND1/IgH translocation (middle inset) and immunohistochemical stain for sox11 (right) in representative cases of plasma cell myelomas ( × 1000). FISH: orange signal representing CCND1gene at chromosome 11q13, green signal representing IgH gene at 14q32 and yellow signal representing fusion of CCND1 and IgH. (1a–c) Plasma cell myeloma positive for t(11;14) showed diffuse strong nuclear positivity for cyclin D1, but was negative for nuclear staining of sox11. Positive granular staining of sox11 was seen only in the cytoplasm. (2a–c) Plasma cell myeloma with +11 showed partial positive nuclear staining of cyclin D1, and negative nuclear staining for sox11. (3a–c) Plasma cell myeloma negative for both t(11;14) and +11 was negative for cyclin D1 and nuclear staining of sox11. The cells showing positive nuclear staining of cyclin D1 were endothelial cells (3b).

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