Table 3 Univariate analysis of prognostic factors for distant disease-free survival in 200 premenopausal patients with lymph node-negative breast cancer
Factor | Distant recurrence | Hazard ratio | 95% Confidence interval | P-value | |
|---|---|---|---|---|---|
No. | % | ||||
Ki67 | |||||
Low | 15 | 11 | 1.0 | ||
High | 17 | 27 | 2.7 | 1.3–5.4 | 0.005 |
Age, years | 0.91 | 0.85–0.96 | 0.001 | ||
Age, years | |||||
≥50 | 3 | 6 | 1.0 | ||
<50 | 29 | 19 | 3.5 | 1.1–11 | 0.04 |
Size, mm | |||||
≤20 | 20 | 13 | 1.0 | ||
>20 | 12 | 24 | 2.0 | 0.95–4.0 | 0.07 |
Histological grade a | |||||
1 | 5 | 8 | 1.0 | ||
2 | 10 | 14 | 1.8 | 0.61–5.2 | 0.29 |
3 | 17 | 25 | 3.4 | 1.3–9.3 | 0.02 |
Histological grade | |||||
1+2 | 15 | 12 | 1.0 | ||
3 | 17 | 25 | 2.4 | 1.2–4.9 | 0.01 |
Histological grade | |||||
1 | 5 | 8 | 1.0 | ||
2+3 | 27 | 20 | 2.6 | 0.99–6.7 | 0.05 |
ER | |||||
Positive | 15 | 11 | 1.0 | ||
Negative | 17 | 25 | 2.4 | 1.2–4.9 | 0.01 |
PR | |||||
Positive | 16 | 11 | 1.0 | ||
Negative | 16 | 28 | 3.0 | 1.5–5.9 | 0.002 |
HER2 | |||||
Negative | 17 | 10 | 1.0 | ||
Positive | 11 | 50 | 6.7 | 3.1–14 | <0.001 |
