Figure 2
From: Micropapillary ductal carcinoma in situ of the breast: an inter-institutional study
Representative micrographs of micropapillary ductal carcinoma in situ. Low nuclear grade micropapillary ductal carcinoma in situ: numerous club-like micropapillae are formed by monomorphic cells with rounded, uniform, and equidistant nuclei. The chromatin is finely dispersed. Mitotic figures are absent (a and b). Intermediate nuclear grade micropapillary ductal carcinoma in situ: micropapillae of different shapes are formed by cells displaying pleomorphic nuclei with increased nuclear/cytoplasmic ratio, occasional nucleoli, and coarse chromatin (c and d). High nuclear grade micropapillary ductal carcinoma in situ: irregular micropapillae are formed by atypical cells with large, markedly pleomorphic, poorly polarized nuclei and apparent nucleoli. Mitotic figures and necrotic cellular debris are present (e and f). Micropapillary structures are seen floating within the lumen of ducts regardless of the nuclear grade.
