Table 1 Clinical and pathological characteristics of micropapillary ductal carcinomas in situ stratified by nuclear grade
From: Micropapillary ductal carcinoma in situ of the breast: an inter-institutional study
Nuclear grade | |||||
---|---|---|---|---|---|
Total | Low (%) | Intermediate (%) | High (%) | P-value | |
55 | 13 (24) | 16 (29) | 26 (47) | ||
Age at diagnosis | |||||
40–49 | 10 | 1 (10) | 2 (20) | 7 (70) | 0.268 |
50–59 | 25 | 8 (32) | 7 (28) | 10 (40) | |
60–69 | 16 | 2 (12) | 7 (44) | 7 (44) | |
≥70 | 4 | 2 (50) | 0 | 2 (50) | |
Extent (mm) | |||||
≤15 | 27 | 10 (37) | 10 (37) | 7 (26) | 0.026 |
16–39 | 9 | 1(11) | 1 (11) | 7 (78) | |
≥40 | 19 | 2 (11) | 5 (26) | 12 (63) | |
Necrosis | |||||
Yes | 34 | 2 (6) | 10 (29) | 22 (65) | <0.001 |
No | 21 | 11 (52) | 6 (29) | 4 (19) | |
Microinvasion | |||||
Yes | 7 | 0 | 0 | 7 (100) | 0.017 |
No | 48 | 13 (27) | 16 (33) | 19 (40) | |
Estrogen receptor a | |||||
≥10% | 37 | 12 (32) | 12 (32) | 13 (36) | 0.004 |
<10% | 17 | 0 | 4 (24) | 13 (76) | |
Progesterone receptor a | |||||
<10% | 31 | 10 (32) | 12 (39) | 9 (29) | 0.005 |
≥10% | 23 | 2 (9) | 4 (17) | 17 (74) | |
HER2 a | |||||
Positive | 24 | 0 | 4 (17) | 20 (83) | <0.001 |
Negative | 30 | 12 (40) | 12 (40) | 6 (20) | |
Ki67 a | |||||
≥10% | 34 | 2 (6) | 8 (23) | 24 (71) | 0.001 |
<10% | 20 | 10 (50) | 8 (40) | 2 (10) | |
p53 a | |||||
≥10% | 22 | 2 (9) | 8 (36) | 12 (55) | 0.173 |
<10% | 32 | 10 (31) | 8 (25) | 14 (44) | |
Epithelial growth factor receptor a | |||||
≥10% | 6 | 0 | 1 (20) | 5 (80) | |
<10% | 48 | 12 (25) | 15 (31) | 21 (44) | 0.283 |