Table 1 Clinical and pathological characteristics of micropapillary ductal carcinomas in situ stratified by nuclear grade

From: Micropapillary ductal carcinoma in situ of the breast: an inter-institutional study

  

Nuclear grade

 
 

Total

Low (%)

Intermediate (%)

High (%)

P-value

 

55

13 (24)

16 (29)

26 (47)

 

Age at diagnosis

 40–49

10

1 (10)

2 (20)

7 (70)

0.268

 50–59

25

8 (32)

7 (28)

10 (40)

 

 60–69

16

2 (12)

7 (44)

7 (44)

 

 ≥70

4

2 (50)

0

2 (50)

 

Extent (mm)

 ≤15

27

10 (37)

10 (37)

7 (26)

0.026

 16–39

9

1(11)

1 (11)

7 (78)

 

 ≥40

19

2 (11)

5 (26)

12 (63)

 

Necrosis

 Yes

34

2 (6)

10 (29)

22 (65)

<0.001

 No

21

11 (52)

6 (29)

4 (19)

 

Microinvasion

 Yes

7

0

0

7 (100)

0.017

 No

48

13 (27)

16 (33)

19 (40)

 

Estrogen receptor a

 ≥10%

37

12 (32)

12 (32)

13 (36)

0.004

 <10%

17

0

4 (24)

13 (76)

 

Progesterone receptor a

 <10%

31

10 (32)

12 (39)

9 (29)

0.005

 ≥10%

23

2 (9)

4 (17)

17 (74)

 

HER2 a

 Positive

24

0

4 (17)

20 (83)

<0.001

 Negative

30

12 (40)

12 (40)

6 (20)

 

Ki67 a

 ≥10%

34

2 (6)

8 (23)

24 (71)

0.001

 <10%

20

10 (50)

8 (40)

2 (10)

 

p53 a

 ≥10%

22

2 (9)

8 (36)

12 (55)

0.173

 <10%

32

10 (31)

8 (25)

14 (44)

 

Epithelial growth factor receptor a

 ≥10%

6

0

1 (20)

5 (80)

 

 <10%

48

12 (25)

15 (31)

21 (44)

0.283

  1. aSections not available for immunophenotyping: 1 low nuclear grade micropapillary ductal carcinomas in situ. Bold values are statistically significant P-value.