Table 5 Criteria for differential diagnosis of sarcomatoid pleural tumors
From: Sarcomatoid mesothelioma: a clinical–pathologic correlation of 326 cases
Sarcomatoid mesothelioma | Sarcomatoid carcinoma | Monophasic synovial sarcoma | Malignant solitary fibrous tumor | |
|---|---|---|---|---|
Gross distribution, clinical | Pleural-based tumor, confluent, diffusely infiltrating. Very rarely localized. Usually in males of >50 years | Usually more localized deposits, rarely generalized. Frequently peripheral (often apical) lung mass | Any site but usually relatively circumscribed. Rarely more generalized, often in younger age (40–50 years) | Usually fairly localized, in younger age (30–50 years) |
Immunohistochemistry | CK+ (usually) | CK+, other carcinoma-related markers may also be positive | CK+ (focal) CD99+ BCL2+ (rarely calretinin+) | CK–, C34+ Bcl2+ CD99+ |
Other | Electron microscopy rarely contributory | Electron microscopy rarely contributory | t(X;18) | Characteristic histological appearances in benign areas |
