Table 1 Clinical and genetic details of the t(11;18)(q21;q21)-positive and -negative gastric MALT lymphomas

Case	Age	Sex	t(11;18)	Location of the MALT1 break point	FISH documented genetic aberrations ^a	Hp	Staging	Therapy ^b	Follow-up
LL31	M	52	+	Intron 4	−	+	I AE	Gastrectomy	CR
LL53	M	52	+	Intron 4	−	−	NA	NA	NA
LL57	F	68	+	Intron 4	−	+	IV^c	Gastrectomy + CT	CR
L87	M	54	+	Intron 4	−	+	I AE	Gastrectomy	CR
LL29	F	26	+	Intron 7	−	+	I AE	Gastrectomy	CR
LL51	M	52	+	Intron 7	−	−	I AE	Gastrectomy	Relapse in the lung 8 years after initial diagnosis with CR after secondary treatment
LL27	M	46	+	Intron 7	−	+	I AE	Gastrectomy	Relapse in the stomach 1 year after initial diagnosis, with PR and SD after recurrent therapy (surg, RT, CT, Hp eradication)
LL79	M	42	+	Intron 7	−	+	I AE	Gastrectomy	CR
LL39	F	60	+	Intron 8	−	+	I AE	Gastrectomy	CR
LL72	M	42	+	Intron 8	−	+	II	Gastrectomy + RT	CR
LL52	F	47	−	−	−	+	I AE	Gastrectomy	CR
LL5	F	63	−	−	Trisomy 3 and 18	−	I AE	Gastrectomy	CR
LL75	F	41	−	−	Trisomy 3; MALT1 amplification	+	I AE	Gastrectomy	CR
LL34	F	75	−	−	−	+	I AE	Gastrectomy	CR

M, male; F, female; RT, radiotherapy; CT, chemotherapy; CR, complete response; PR, partial response; SD, stable disease; Hp, Helicobacter pylori; NA, not available.
^a All 14 cases were analyzed by interphase FISH for structural and numerical aberrations of the BCL10 (1p22), FOXP1 (3p13), API2 (11q21), IGH (14q32) and MALT1 (18q21) genes, as previously described. Centromere-specific probes were used to verify aneuploidy of chromosomes 3 and 18.
^b Cases were selected on availability of gastrectomy specimens. As all diagnoses were made in the late 1980s before gastric MALT lymphoma was known to be related to chronic Helicobacter pylori infection, surgical resection of the lymphoma site was the first choice of treatment in all patients.
^c In case LL57, An Arbor stage IV was diagnosed because of bone marrow involvement.

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