Table 2 Chromosomal regions with differential expression composing the API2-MALT signature and relevant genes mapped to these regions

From: Comparative expressed sequence hybridization studies of t(11;18)(q21;q21)-positive and -negative gastric MALT lymphomas reveal both unique and overlapping gene programs

Chromosomal regions with differential expression composing the API2-MALT1 signature a

Some relevant genes involved in the biology of API2-MALT1,b in the NF-κB pathway, and in hematopoietic oncogenesis

1p35-p36.1/1p13/1q21-q24/1q42-q43

-/-/-/NID

2p24-p25/2q12/2q32/2q36-q37

-/ZAP70/-/COR1, COL4A2, GPC1

3p24/3p14-p21/3q23

-/-/-

4p15-p16/4q13/4q27-q28/4q34-q35

-/EREG/-/-

5p14-p15.2/5q31-q32

-/-

6p25/6p21.3-p22/6q16

-/PSMB8, OSF2/-

7p14-p21/7q35

AQP1/-

8p12/8q24

GTF2E2/-

9p12-p13/9q21-q22/9q31-q33/9q34

-/OMD, SYK/COX1, ZFP-37/LCN7

10p11.2-p12/10q24-q26

-/PIK3AP1, IKK1, NFKB2

11p12-p14/11q12-q13/11q22/11q23/11q25

TRAF6/-/MMP10, RELA/MMP3/-

12p12-p13/12q12-q13/12q21/12q23

MGP, MAGP2/DCN, VDR/WT1/-

13q12/13q22-q31

-/-

14q12-q13/14q22-q24/14q31

NFKBIA/PTGER2/-

15q22-q24

-

16p12-p13.3

MPF, TNA

17p13/17q12-q21/17q23

P53/CCL2, CCL5, CCL7/-

18q12

-

19p12-p13.3/19q13.2-q13.4

CRLF1, KLF1, VAV1/TNNT1, CLEC11A

20p11.2-p12/20q12-q13

THBD/WISP2, SLPI, PLCG1

22q13

-

Xp21/Xq22-q26

-/BTK

  1. a Bold are the regions with differential expression found in at least 50% of the cases.
  2. b Genes found to be dysregulated in API2-MALT1-transfected NIH 3T3 cell lines by Stoffel et al.33 are given; genes found to have a role in the NF-κB pathway and/or biology of hematopoietic cells and oncogenesis are given in bold.
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