Table 3 Chromosomal regions with differential expression composing the gastric MALT lymphoma signature and relevant genes mapped to these regions

From: Comparative expressed sequence hybridization studies of t(11;18)(q21;q21)-positive and -negative gastric MALT lymphomas reveal both unique and overlapping gene programs

Chromosomal regions with differential expression in gastric MALT lymphoma as compared to spleen a

Some relevant genes involved in the biology of hematopoietic cells and oncogenesis b

1p33-p36.3 ↓/1p22-p31 ↓/1q21-q24 ↓/1q31 ↓/1q32 ↓/1q41-q43 ↓

CDC2L1, FGR, CDC42, LCK/BCL10/AF1Q, AKNT, CD32, PBX1/IRGS18, RGS1, RGS13, RGS2, CD45/CD34/-

2p25 ↑/2p15-p23 ↑/2q12-q14.1 ↑/2q23 ↑/2q33 ↑/2q37 ↓

-/MSH2/IL1, ZAP70/-/CASP8/SP140

3p23-p24 ↓/3p13-p22 ↓/3p12 ↑/3q13 ↑/3q21-q23 ↓/3q26.1-q26.2 ↑

CCR4/FOXP1, PDCD6IP, ITGA9, CTNNB1, MST1R, RASSF1A, HYAL1-3/-/-/RYK, EPHB1/TRAIL, WIG1

4p15.3-p16 ↑/4q12-q22 ↑/4q23-q25 ↑/4q26-q27 ↑/4q28-q35 ↑

FGFR3, RGS12/KIT, CXCL9, IL8, BCA1/NFKB1/FGF2, IL2, IL21, FGF2/-

5q15-q23 ↑/5q31-q32 ↓

PPIC, IL3, GM-CSF, IL4, IL5, IL13/CDC25C, EGR1, GRAF, FACL6

6p21.2-p24 ↓/6q12-q16 ↑

IRF4, DEK, HLA, PBX2, TNFA, UBD, LTA, CCND3, DDR1, MHC2, DAXX, BAK, ETV7, CDKN1A, PIM1/-

7p14-p21 ↓/7q22 ↓/7q32-q35 ↓

IL6, HOXA/TCRB

8p21-p22 ↓/8q21.2-q22 ↑

TNFRSF1-D/E2FS, RAD54, BAALC

9p21 ↓/9q21-q22 ↑/9q31-q32 ↓

CDKN2A-B, TEK/ANXA1, NTRK2, SYK, ROR2, PTCH, PHF2/TAL2

10q21 ↑/10q22 ↓

EGR/-

11p15 ↑/11q12-q13 ↑/11q21-q22 ↑/11q23 ↓

NUP98, SWAP70/NUP98, LMO1, CCND1, MS4A, PTPRC, RELA/LPXN, API2/MLL, IL10RA, CXCR5, ZNF145

12p11.2-p13 ↑/12q13 ↓/12q14-q15 ↓/12q24.2 ↓

CCND2, ETV6, TEL, CD27, KRAS2/-

13p11.2-p13 ↑/13q13-q14 ↓/13q21 ↑/13q22-q32 ↑

-/DBM, DLEU2, ARL11/PCDH9/SPRY2, Y918

14p11.2-p13 ↑ /14q13-q21 ↑/14q24 ↑/14q31-q32 ↓

-/NFKBIA/FOS, RGS6, TGFB3/TCL1A, TCL1B

15p11.2-p13 ↑/15q22-q26 ↓

-/PML, CSK, KIP2, NTRK3

16q13 ↓/16q22-q23 ↓

-/AMLCR2

17p13 ↓/17q23-q24 ↓

P53, TNK1/ RGS9, PRKAR1A

18q21-q23 ↑

MAPK4, MADH4, MALT1, BCL2, FVT1

19q13.2 ↓

INSR, TYK2, CDC37, ILF3, TRAP, JUNB, CD79a

20p12 ↑/20q13.3 ↓

PCNA/-

21p11.2-p13 ↑/21q11.2-q21 ↑

-/IL10RB, AML1

22p13-p12 ↑/22q13 ↑

-/MKL1, BAFFR

Xp11.4-p21 ↑/Xq21 ↑/Xq22 ↑/Xq25 ↑/Xq27 ↑

-/BTK, ITMA2/-/XLP, XPNEP2/-

  1. a Bold are the regions with differential expression found in the 3 gastric MALT lymphoma groups; regions found to be differentially expressed in 2 of the 3 groups are italicized; others are the differentially expressed regions found in 1 of the 3 groups.
  2. b Genes encoding proteins with previously reported altered expression in marginal zone lymphoma and/or NK-κB pathway are italicized. Genes were selected from the human genome map (http://www.ensemble.org).
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