Figure 4 | Modern Pathology

Figure 4

From: Lipid droplet-associated PAT-proteins show frequent and differential expression in neoplastic steatogenesis

Figure 4

Perilipin and adipophilin surround lipid droplets in hepatocellular adenoma and carcinoma. Confocal laser scanning microscopy of human hepatocellular adenoma (a1–4) and carcinoma (b1–4, c1–4) shows the presence of numerous Nile red-positive lipid droplets (red, a2–c2) surrounded by adipophilin (green, a1, b1) and perilipin (green, c1). Adipophilin (green, d1) and perilipin (red, d2) are differentially expressed in cytokeratin 8/18 (CK8/18, blue, d3)-positive hepatocellular carcinoma cells with mutually exclusive localization of adipophilin (green arrow) or perilipin (red arrow) or colocalization of both (yellow arrow, d4). BF, bright field. Bars=25 μm.

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