Table 2 Comparisons of survivin expression between responders and nonresponders

From: Aberrant survivin expression in endometrial hyperplasia: another mechanism of progestin resistance

 

Preprogestin

Postprogestin

Post–pre difference

P-values

 

Mean (range)

Mean (range)

Mean (s.d.)

 

Responders

 Epithelial cells index (range)

Nuclear

78 (20–135)

4 (0–25)

–74 (34.6)

<0.001

Cytoplasmic

114 (70–200)

14 (0–60)

−100 (42.9)

<0.001

 Stromal cells index (range)

Nuclear

18 (3–40)

3 (0–15)

–15 (11.2)

0.01

Cytoplasmic

49 (0–90)

10 (0–30)

−39 (28.5)

0.02

Non-responders

 Epithelial cells index (range)

Nuclear

70 (30–135)

75 (40–120)

5 (42.9)

0.8

Cytoplasmic

128 (70–180)

89 (50–110)

−39 (36.1)

0.06

 Stromal cells index (range)

Nuclear

18 (7–30)

12 (3–25)

−6 (8.7)

0.2

Cytoplasmic

56 (20–90)

36 (20–70)

−20 (30.1)

0.2

  1. *Survivin staining index was measured on the basis of the morphological nonresponding areas only.