Table 1 Clinicopathological data and marker expression in 62 resected undifferentiated LCCs of the lung
Samples (no. 29) | Validation cohort (no. 33) | |||||
|---|---|---|---|---|---|---|
Clinical data | ||||||
Age (years) | 64 (45–80) | 62 (45–83) | ||||
Sex (male/female) | 22/7 | 29/4 | ||||
Mean tumor size (cm) | 4.1 | 4.0 | ||||
Histotype | DSC3 | TTF-1 | DSC3 | TTF-1 | ||
Large-cell carcinoma NOS (ICD-O code 8012/3) | 16/29 | 8/16a | 8/16a | 20/33 | 5/20a | 11/20a |
Large-cell carcinoma, clear-cell variant (ICD-O code 8310/3) | 7/29 | 3/7a | 4/7a | 5/33 | 4/5a | 1/5a |
Large-cell carcinoma, basaloid variant (ICD-O code 8123/3) | 3/29 | 3/3a | 0/3 | 3/33 | 3/3a | 0/3a |
Large-cell carcinoma, lymphoepithelioma-like (ICD-O code 8082/3) | 0/29 | – | – | 1/33 | 1/1a | 0/1 |
Sarcomatoid carcinoma, spindle-cell variant (ICD-O code 8032/3) | 3/29 | 0/3 | 0/3 | 4/33 | 0/4 | 0/4 |
Control groups | ||||||
Squamous carcinoma | 20 | 20/20 | 2/20 | |||
Adenocarcinomas | 20 | 1/20 | 18/20 | |||
Adenosquamous carcinoma | 3 | 3/3 | 3/3 | |||
