Figure 2 | Modern Pathology

Figure 2

From: Expression of Notch-1 and alteration of the E-cadherin/β-catenin cell adhesion complex are observed in primary cutaneous neuroendocrine carcinoma (Merkel cell carcinoma)

Figure 2

Skin metastasis from lung carcinoid: (a) Notch-1 is not expressed in the monomorphous epithelioid cells arranged in insulae with an organoid and trabecular pattern in the dermis (original magnification × 10); inset shows strong Notch-1 expression with a medium-sized vessel in the context of the tumor (internal positive control) (original magnification × 10); (b) Notch-1 is expressed in small capillary vessels whereas tumor cells are negative (original magnification × 20); (c) β-catenin diffuse membranous staining in tumor cells (original magnification × 20); (d) strong E-cadherin membranous staining in the majority of tumor cells (original magnification × 20).

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