Figure 4 | Modern Pathology

Figure 4

From: Expression of Notch-1 and alteration of the E-cadherin/β-catenin cell adhesion complex are observed in primary cutaneous neuroendocrine carcinoma (Merkel cell carcinoma)

Figure 4

Cutaneous melanoma with area of neuroendocrine differentiation: (a) within a vertical growth phase cutaneous melanoma there is an area of neuroendocrine differentiation with trabecular pattern (left), (hematoxylin and eosin stain, original magnification × 20); (b) in such area, neuronal-specific enolase (NSE) immunostaining is seen, thus confirming neuroendocrine differentiation (original magnification × 20); (c) in the neuroendocrine area there is a weaker Notch-1 signal in comparison with the strong cytoplasmic and membranous Notch-1 staining observed in non-neuroendocrine areas (original magnification × 20); (d) strong and diffuse E-cadherin membranous expression is seen in both neuroendocrine and non-neuroendocrine areas (original magnification × 20).

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