Table 3 The sensitivity, specificity, positive predictive value, and negative predictive value of the detection of MDM2 protein overexpression by immunohistochemistry compared with MDM2 amplification by FISH
MDM2 amplification by FISH | MDM2 protein overexpression by immunohistochemistry | |||||
|---|---|---|---|---|---|---|
Resection (%) | Biopsy (%) | Combined (%) | Resection (%) | Biopsy (%) | Combined (%) | |
Sensitivity | 94 | 100 | 96 | 88 | 65 | 76 |
Specificity | 100 | 100 | 100 | 97 | 89 | 93 |
PPV | 100 | 100 | 100 | 94 | 73 | 84 |
NPV | 97 | 100 | 98 | 95 | 85 | 90 |
