Figure 2
From: Podocyte number predicts progression of proteinuria in IgA nephropathy
Relationship of complement activation and podocyte injury in IgAN. (A) Decreased number of WT-1-positive podocytes in IgAN tended to be associated with increased C3 deposition in glomeruli. (B) C5b-9, an activated complement product, which was expressed mainly in glomerular mesangium and partly in subepithelial area (arrow in (a) and arrowhead in (b)). This localization was confirmed by dual staining for laminin (b), in which confocal microscopy revealed some positive C5b-9 deposition (red) outside the laminin-positive GBM (green). Magnifications were 400 for (a), and 600 for (b). The area with positive C5b-9 deposition in IgAN glomeruli was negatively correlated with the podocyte number.
