Figure 2
(a) A 0.6-cm-sized papillary microcarcinoma. (b) Cyclin D1 expression in the same tissue section shown in (a). Most of the tumor cells are strongly positive for cyclin D1, whereas surrounding normal thyroid tissue is negative. (c, d) Magnified views corresponding to the two inboxes (c, black color line; d, red color line) in (b). Cautery artifact produces distorted morphology, rendering accurate diagnosis of invasion difficult at the surgical resection margin. (c) Cyclin D1 immunostain highlights the tumor cells (arrow) in areas exhibiting cautery artifact well. (d) There is an isolated gland (arrow) of tumor cells that is more than 500 μm from the invasive front. (e) A 0.5-cm-sized papillary microcarcinoma. (f) Cyclin D1 immunostain in the same section shown in (e). One isolated gland of tumor cells (arrow) is noted.
