Figure 1
CD90 glycoprotein in cancer tissue. Western blot analysis of tissue-digestion media detected a diffuse CD90 band at ∼27 kDa, which is larger than the calculated molecular weight of CD90 (∼16 kDa) based on the amino-acid sequence. Cancer is characterized as CD90hi and non-cancer as CD90lo. Both peripheral zone and transition zone cancer show increased CD90 expression compared with non-cancer. Expression level does not seem to vary with Gleason scores. Note that the Gleason score applies to the case not necessarily to the specimens obtained for collagenase digestion. The 30-kDa TIMP1 can be used to characterize non-cancer specimens as TIMP1 is synthesized by luminal cells and not cancer cells. PZ, peripheral zone; TZ, transition zone.
