Table 1 Hereditary conditions associated with pheochromocytomas and paragangliomas
From: Adrenal cortical tumors, pheochromocytomas and paragangliomas
Disorder | Chromosome location | Pheo | PGL | Genetics |
---|---|---|---|---|
MEN 2A and 2B | 10q11.2 | + | RET mutation | |
Von Hippel–Lindau | 3p26-29 | + | VHL mutation | |
Neurofibromatosis I | 17q11.2 | + | NF1 mutation | |
Familial PGL1 | 11q23 | + | SDHD mutation | |
Familial PGL2 | 11q13.1 | + | SDHAF2 mutation | |
Familial PGL3 | 1q2 | + | SDHC mutation | |
Familial PGL4 | 1q23-25 | + | + | SDHB mutation |