Figure 1 | Modern Pathology

Figure 1

From: Prognostic implication of MET overexpression in myxofibrosarcomas: an integrative array comparative genomic hybridization, real-time quantitative PCR, immunoblotting, and immunohistochemical analysis

Figure 1

Array comparative genomic hybridization (aCGH) profiling of myxofibrosarcoma showed a colorimetric gene copy number matrix of chromosome 7. Intensities of red and green coloration generated by Java TreeView indicate an increased or decreased signal ratio for each averaged window of 10 probes, respectively. Each row corresponds to an individual average window and each column represents the aCGH profile of chromosome 7 in a tumor sample. Cytoband pattern of chromosome 7 is shown to the left. Recurrent regions of alterations are denoted by vertical lines in the middle, with gains and deletions of candidate oncogenes and tumor suppressor genes indicated in green and red brackets, respectively. The close-up views of loci harboring genes of most interest are shown to the right. (b) Horizontal karyograms of chromosomal region mapped to candidate oncogenes, HGF, CDK6, and MET, in three representative myxofibrosarcoma samples. MFS86 (upper panel) showed no apparent CNAs across these three genes. High-level DNA gains were seen in MFS96b (middle panel) at the loci harboring CDK6 and MET, but not so for HGF. In addition to CDK6 and MET genes, MFS99b (lower panel) showed slight DNA gains at the locus of HGF.

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