Table 4 Results of Cox multivariate analyses in relation to OS and MeFS
Outcome | Variable | Category | RR | 95% CI | P-value |
|---|---|---|---|---|---|
OS | Mitotic rate | <20/10 HPFs | 1.000 | — | <0.0001* |
≥20/10 HPFs | 7.415 | 2.786–19.736 | |||
MET expression | Low expression (<30%) | 1.00 | — | 0.0221* | |
Overexpression (≥30%) | 6.140 | 1.298–29.051 | |||
Tumor depth | Superficial | 1.000 | — | 0.2781 | |
Deep | 1.932 | 0.588–6.355 | |||
AJCC stage | Stages I and II | 1.000 | — | 0.6763 | |
Stage III | 0.792 | 0.264–2.371 | |||
FNCLCC grade | Grade 1 | 1.00 | — | 0.6970 | |
Grades 2 and 3 | 1.253 | 0.402–3.907 | |||
MeFS | Mitotic rate | <20/10 HPFs | 1.000 | — | <0.0001* |
≥20/10 HPFs | 18.289 | 5.506–60.751 | |||
Age | <60 years | 1.000 | — | 0.0003* | |
≥60 years | 5.699 | 2.220 – 14.626 | |||
MET expression | Low expression (<30%) | 1.00 | — | 0.0040* | |
Overexpression (≥30%) | 9.733 | 2.071–45.749 | |||
Necrotic area | <10% | 1.00 | — | 0.0777 | |
≥10% | 2.414 | 0.907–6.427 | |||
Tumor depth | Superficial | 1.000 | — | 0.1159 | |
Deep | 2.642 | 0.787–8.867 | |||
AJCC stage | Stages I and II | 1.00 | — | 0.2020 | |
Stage III | 0.451 | 0.132–1.533 | |||
Tumor size | <6 cm | 1.00 | — | 0.5946 | |
≥6 cm | 0.758 | 0.274–2.101 | |||
FNCLCC grade | Grade 1 | 1.00 | — | 0.9747 | |
Grades 2 and 3 | 1.021 | 0.279–3.739 |
