Figure 3

Distribution of minichromosome maintenance protein 7 (MCM7) labeling index by a pathologist observer (observer) and an automated cellular imaging system (ACIS). (a) Normal quantile plots and frequency distribution of binned data indicate skewed distribution of the MCM7 labeling index toward the lower end. Patterns of distribution are similar in both observer- and ACIS-derived data. (b) Correlative analysis between observer- and ACIS-derived MCM7 labeling indexes shows significant correlation. (c) Correlation between MCM7 labeling indexes produced by the observer and the ACIS. (d) Correlation between ACIS-derived MCM7 labeling indexes of duplicate samples from the arrays.