Figure 6
APC (5q22.2) copy number and expression in the molecular subtypes of breast cancer. (a) Frequency of APC (5q22.2) loss, as defined by microarray-based comparative genomic hybridization performed with the 32K bacterial artificial chromosome tiling path array,48 in a previously published cohort of 95 grade 3 invasive breast cancers48, 49 according to the molecular subtypes of breast cancer as defined by the immunohistochemical surrogate described by Nielsen et al.34 (b) Correlations between APC mRNA expression levels, as defined by the WG6 Illumina expression arrays (ArrayExpress http://www.ebi.ac.uk/microarray-as/ae/; accession number E-TABM-543)49 and APC loss (as defined by microarray-based comparative genomic hybridization performed with the 32K bacterial artificial chromosome tiling path array48) in basal-like breast cancers (n=13).
