Table 1 Distribution of CD3 scores in the tumor front, center, and the intraepithelial compartment, in all cases and in subgroups based on MSI screening status and CIMP status

From: Colorectal cancer prognosis depends on T-cell infiltration and molecular characteristics of the tumor

Tumor compartment

Front

Pa

Center

Pa

Intraepithelially

Pa

 

CD3 score

 

CD3 score

 

CD3 score

 
 

1–2

3–4

 

1–2

3–4

 

1–2

3–4

 

All cases

344

117

 

386

97

 

377

101

 

MSI screening status, n (%)

  

0.004

  

0.075

  

0.00027

 MSI

42 (12)

27 (24)

 

52 (14)

20 (21)

 

45 (12)

27 (27)

 

 MSS

294 (88)

86 (76)

 

323 (86)

74 (79)

 

320 (88)

72 (73)

 

CIMP status, n (%)

  

0.292

  

0.036

  

0.001

 CIMP-negativeb

173 (50)

55 (47)

 

190 (49)

53 (55)

 

194 (51)

46 (46)

 

 CIMP-lowb

134 (39)

43 (37)

 

155 (40)

27 (28)

 

148 (39)

32 (32)

 

 CIMP-highb

37 (11)

19 (16)

 

41 (11)

17 (18)

 

35 (9)

23 (23)

 
  1. Abbreviations: CIMP, CpG island methylator phenotype, according to an eight-gene panel; MSI, microsatellite instability; MSS, microsatellite stable.
  2. aχ2 test.
  3. bCIMP-negative, 0 genes hypermethylated; CIMP-low, 1–5 genes hypermethylated; CIMP-high, 6–8 genes hypermethylated.
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