Table 2 Clinical and molecular characteristics of colorectal cancer cases according to total CD3 score

From: Colorectal cancer prognosis depends on T-cell infiltration and molecular characteristics of the tumor

 

Total CD3 score

 

Total a

3–4

5–6

7–12

Pb

Frequency, n (%)

455

147 (32)

163 (36)

145 (32)

 

Age at diagnosis, median years (range)

71 (26–93)

70 (37–91)

71 (30–89)

73 (26–93)

0.067

Sex, n (%)

0.914

 Men

248 (55)

79 (54)

91 (56)

78 (54)

 

 Women

207 (45)

68 (46)

72 (44)

67 (46)

 

Tumor site, n (%)a

0.335

 Right-sided colon

140 (31)

38 (26)

48 (29)

54 (38)

 

 Left-sided colon

141 (31)

48 (33)

51 (31)

42 (29)

 

 Rectum

170 (38)

58 (40)

64 (39)

48 (33)

 

Stage, n (%)a

    

<0.0001

 I

74 (17)

10 (7)

24 (15)

40 (28)

 

 II

178 (40)

40 (28)

69 (43)

69 (49)

 

 III

92 (21)

38 (27)

34 (21)

20 (14)

 

 IV

100 (23)

54 (38)

33 (21)

13 (9)

 

Tumor grade, n (%)a

0.002

 Well/well-to-moderately differentiated

218 (49)

54 (38)

83 (51)

81 (58)

 

 Moderately-to-poorly/poorly differentiated

229 (51)

90 (62)

80 (49)

59 (42)

 

Histology type, n (%)a

0.328

 Non-mucinous

384 (86)

119 (83)

138 (86)

127 (89)

 

 Mucinous

64 (14)

25 (17)

23 (14)

16 (11)

 

Adjuvant chemotherapy, n (%)a

0.178

 No

381 (86)

117 (82)

140 (89)

124 (87)

 

 Yes

62 (14)

26 (18)

17 (11)

19 (13)

 

Preoperative radiation, n (%)c

0.016

 No

68 (40)

17 (29)

24 (38)

27 (56)

 

 Yes

102 (60)

41 (71)

40 (62)

21 (44)

 

MSI screening status, n (%)a

0.003

 MSI

69 (16)

12 (8)

25 (16)

32 (23)

 

 MSS

374 (84)

133 (92)

133 (84)

108 (77)

 

CIMP status, n (%)

    

0.104

 CIMP-negatived

225 (49)

75 (51)

81 (50)

69 (48)

 

 CIMP-lowd

174 (38)

61 (41)

63 (39)

50 (34)

 

 CIMP-highd

56 (12)

11 (7)

19 (12)

26 (18)

 

BRAF V600E, n (%)a

0.225

 Wild type

386 (86)

124 (86)

144 (89)

118 (82)

 

 Mutated

65 (14)

21 (14)

18 (11)

26 (18)

 
  1. Abbreviations: CIMP, CpG island methylator phenotype, according to an eight-gene panel; MSI, microsatellite instability; MSS, microsatellite stable.
  2. aTotal CD3 score could be calculated in 455 of the 484 colorectal cancer tumors included in this study. Among these, missing cases were present in the following variables: tumor site, 4; stage, 11; grade, 8; histology type, 7; adjuvant chemotherapy, 12; MSI screening status, 12; BRAF mutation status, 4.
  3. bKruskall–Wallis test for continuous variables, χ2 test for categorical variables.
  4. cPreoperative radiation therapy in rectal cancer cases only.
  5. dCIMP-negative, 0 genes hypermethylated; CIMP-low, 1–5 genes hypermethylated; CIMP-high, 6–8 genes hypermethylated.
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