Table 3 HRs and 95% CIs for cancer-specific death in colorectal cancer subgroups based on total CD3 score

From: Colorectal cancer prognosis depends on T-cell infiltration and molecular characteristics of the tumor

 

Cases/cancer-specific deaths (n)

Univariate

Multivariate HR (95% CI) a

Multivariate adjusted for MSI screening status a

Multivariate adjusted for CIMP status a,b

Total CD3 score

 3–4

86/48

1

1

1

1

 5–6

106/43

0.67 (0.44–1.01)

1.41 (0.89–2.23)

1.43 (0.90–2.28)

1.39 (0.88–2.21)

 7–12

116/18

0.23 (0.12–0.38)

0.57 (0.31–1.00)

0.57 (0.31–1.02)

0.55 (0.30–0.99)

  1. Abbreviations: CI, confidence interval; CIMP, CpG island methylator phenotype, according to an eight-gene panel; HR, hazard ratio, determined by Cox proportional hazard models; MSI, microsatellite instability.
  2. aAdjusted for sex, age, tumor site, tumor stage, and adjuvant chemotherapy.
  3. CIMP-negative, 0 genes hypermethylated; CIMP-low, 1–5 genes hypermethylated; CIMP-high, 6–8 genes hypermethylated.
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