Table 1 Patient characteristics
Case 1 | Case 2 | Case 3 | Case 4 | ||
|---|---|---|---|---|---|
Sex | Female | Male | Male | Female | |
Clinical presentation | Age (years) | 13 | 23 | 32 | 55 |
Underlying disease | Aplastic anaemia | Acute myeloid leukaemia | Acute lymphoblastic leukaemia | Acute myeloid leukaemia | |
Bone marrow transplantation conditioning procedure | Cyclophosphamide | Total body irradiation | Total body irradiation | Unknown | |
Transplant type | Allogeneic, matched sibling | Allogeneic, sibling | Allogeneic, sibling | Autologous | |
Time from bone marrow transplantation to presentation (in years) | 2 years 9 months | 12 | 16 | 2 | |
Symptoms | Dyspnoea, chest pain | Dyspnoea, phlegm, weight loss | Dyspnoea, bronchitis | Dyspnoea, pyrexia | |
Pneumothorax | Bilateral | Right | Bilateral | Left | |
Extra-pulmonary graft-vs host disease | No | Yes | No | No | |
CT | Patchy visceral pleural thickening | Visceral pleural thickening | Non-uniform visceral pleural thickening | Pleuroparenchymal irregularity consistent with fibrosis | |
Subpleural blebs | Pleuroparenchymal tags | Subpleural blebs | Fine interstitial fibrosis | ||
Mosaicism | Mosaicism | Mosaicism | Ground-glass opacification | ||
Pathology | Method of sampling | Video-assisted thoracoscopic biopsy | Postmortem | Video-assisted thoracoscopic biopsy | Postmortem |
Pleuroparen chymal fibroelastosis | Yes | Yes | Yes | Yes | |
Obliterative bronchiolitis | Yes | Yes | Yes | Yes | |
Follow-up | Progressive disease | Died 12 years after bone marrow transplantation | Stable disease | Died 5 years after bone marrow transplantation |
