Figure 3 | Modern Pathology

Figure 3

From: Assessment of invasion in lung adenocarcinoma classification, including adenocarcinoma in situ and minimally invasive adenocarcinoma

Figure 3

Case-based assessment of invasive histology in a lepidic predominant adenocarcinoma. (a) A low-power view of a tumor with lepidic pattern at its periphery and an area of central scarring. The lepidic tumor component in panel b is characterized by the same features of alveolar growth seen in adenocarcinoma in situ, shown at higher magnification in the inset. The circle shows an area transitioning to invasion, with evident papillary structures. (c) Further evidence of invasion with more fibrous tissue, irregular glands and micropapillae. (d) Frank invasion with small nests and a single cell in the desmoplastic stroma. The cells of the invasive component are more columnar and of higher nuclear grade (inset). (H&E stains, original magnification (a) × 10, (b) × 25, (c) × 50, (d) × 150 and both insets × 100).

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