Table 3 Comparison of the PMR values of the 15-CpG island loci according to breast cancer subtype
Gene | PMR value (median (interquartile range)) | P-valuea | ||||
|---|---|---|---|---|---|---|
Luminal A (n=36) | Luminal B (n=33) | Luminal–HER2 (n=30) | HER2 enriched (n=40) | Basal-like (n=40) | ||
APC | 0 (0–19.92) | 27.63 (0–47.88) | 15.68 (0–26.81) | 1.49 (0–16.55) | 0 (0) | <0.001 |
DLEC1 | 3.03 (0.01–10.84) | 8.02 (0.22–20.11) | 9.25 (1.21–17.11) | 0.10 (0–9.77) | 0 (0–0.01) | <0.001 |
GRIN2B | 0 (0–5.60) | 1.13 (0–18.58) | 2.93 (0–16.68) | 3.61 (0–17.46) | 0 (0–0.65) | 0.006 |
GSTP1 | 0.02 (0–1.31) | 0.75 (0–5.61) | 5.40 (1.09–16.62) | 0 (0–8.79) | 0 (0) | <0.001 |
HOXA1 | 18.19 (4.03–35.40) | 37.21 (20.23–49.73) | 23.08 (17.76–33.93) | 20.02 (10.75–47.13) | 0.01 (0–5.05) | <0.001 |
HOXA10 | 0.01 (0–1.79) | 0.66 (0–14.50) | 0.12 (0–1.99) | 0 (0–5.51) | 0 (0–0.71) | 0.092 |
IGF2 | 0 (0–0.45) | 0 (0–0.98) | 0 (0–3.57) | 0 (0–0.31) | 0 (0–0.01) | 0.064 |
MT1G | 0 (0–2.14) | 0.61 (0–6.90) | 6.06 (0.11–13.81) | 1.69 (0–7.45) | 0.06 (0–1.41) | 0.003 |
RARB | 0.07 (0–1.70) | 0.43 (0–16.0) | 2.51 (0–20.33) | 1.77 (0–8.75) | 0.17 (0–1.71) | 0.016 |
RASSF1A | 19.95 (8.97–44.91) | 27.43 (12.09–35.76) | 17.67 (9.68–32.85) | 14.75 (2.51–29.96) | 0 (0–2.25) | <0.001 |
RUNX3 | 0 (0–4.67) | 1.18 (0–6.20) | 2.99 (0–7.11) | 0 (0) | 0 (0) | <0.001 |
SCGB3A1 | 0 (0–8.34) | 0 (0–12.94) | 8.24 (1.83–23.50) | 0 (0–7.94) | 0 (0) | <0.001 |
SFRP1 | 2.48 (0–16.53) | 7.80 (1.51–44.88) | 10.81 (2.52–23.50) | 3.24 (0–10.66) | 0.19 (0–1.20) | <0.001 |
SFRP4 | 0 (0–2.04) | 0 (0–4.06) | 0 (0–8.58) | 0 (0–5.10) | 0 (0–1.00) | 0.205 |
TMEFF2 | 13.66 (5.01–25.45) | 27.67 (7.41–39.29) | 25.08 (15.82–37.77) | 21.84 (6.26–45.93) | 1.75 (0.52–5.72) | <0.001 |
